Wednesday, October 30, 2013

DEFINITION

bio DEFINITION Osteogenisis imperfecta (OI) is a rargon genetic disorder of collagen deduction associated with colossal spectrum of musculoskeletal problems, al nigh notably bowing and fractures of the extremities, muscle constructor weakness, ligamentous laxity, and spinal deformities. (Binder, 386). Other collagen-containing extraskeletal tissues, such as the sclerae, the teeth, and the heart valves argon also affected to a variable degree. OI has a vulgar feature of bony fragility associated with defective formation of collagen by osteoblasts and fibroblasts.
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(Smith, 1983, 13) This disease, involving defective development of the connective tissues, is usually the root of the autosomal dominant gene, but can also be the outgrowth of the autosomal recessive gene. Spontaneous mutations are common and the clinical presentation of the disease remains to be quite broad. (Binder, 386) OI is most commonly referred to as brittle bones, but another(prenominal) name calling include: fragilitas ossium, hyp...If you want to get a replete(p) essay, order it on our website: OrderCustomPaper.com

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